Dr. Prasanth Manohar, Ph.D., – PHAGElogist

Essential genome of phages

Defining the essential genome of diverse phages with phage Tn-seq Systematic mapping of bacteriophage gene essentiality with HIDEN-SEQ Most tailed phages have genomes of 50–200 kb in size, of which one…

The Big Loss: ” RIP The First Lady of Phage Research”

With "Phage Queen Herself" Dr. Elizabeth Kutter

Read about latest phage research in Nature:

https://www.nature.com/subjects/phage-biology Phage biology is the scientific discipline concerned with the study of all biological aspects of bacteriophages (phages), which are viruses that infect bacteria. This includes the distribution, biochemistry, physiology,…

Targeted phages curb Crohn’s-linked gut inflammation

Phage intervention improves colitis and response to corticosteroids by attenuating virulence of Crohn’s disease–associated bacteria https://www.science.org/doi/10.1126/scitranslmed.adz4589 Abstract Adherent-invasive Escherichia coli (AIEC) exhibits proinflammatory properties and has been implicated in the pathogenesis of…

Submit your research: Topical collection on ssRNA phage

JOVE: TOPICAL COLLECTIONS Experimental and Structural Approaches to ssRNA Phage Biology https://www.jove.com/methods-collections/5270/experimental-and-structural-approaches-to-ssrna-phage-biology Collection Overview The proposed collection, would feature novel techniques and mechanistic discoveries that advance the study of ssRNA…

ATLAS – Klebsiella phage receptor-binding protein

A new study from Mostowy's lab in Poland on "Structural modularity of receptor-binding proteins underlies host-range strategy diversification in Klebsiella pneumoniae phages" shows the importance of using structural modelling in determining phage-bacterial…

How can polyvalent phage shape bacterial dynamics?

A new paper published in J. Virology, "A polyvalent phage shapes bacterial dynamics" Phages are the most abundant biological entity on the planet, but polyvalent phages that infect multiple bacterial…

Phage-derived proteins can detach the bacterial pilus

Recently published in JBac, "Phage-derived proteins and conjugates induce pilus detachment" Acinetobacter species are environmental bacteria and members of the ESKAPE pathogens, associated with hospital-acquired infections among immunocompromised patients. Rising…

Phage Engineering

Natural phages Vs. Synthetic phages Image from Huss and Raman, 2020. These are some of the important articles in phage engineering / synthetic phages for applications. https://doi.org/10.1016/j.copbio.2019.11.013 https://doi.org/10.7554/eLife.63775 https://www.cell.com/iscience/fulltext/S2589-0042(25)02560-X https://doi.org/10.1016/j.cell.2019.09.015…

Map of Clinical Phage Therapy

The Global Map of Clinical Phage Therapyhttps://www.thephagetherapy.com/p/phagetrials.html An interactive global atlas of bacteriophage therapy clinical trials powered by live ClinicalTrials.gov data.