Dr. Prasanth Manohar, Ph.D., – PHAGElogist

Submit your research: Topical collection on ssRNA phage

JOVE: TOPICAL COLLECTIONS Experimental and Structural Approaches to ssRNA Phage Biology https://www.jove.com/methods-collections/5270/experimental-and-structural-approaches-to-ssrna-phage-biology Collection Overview The proposed collection, would feature novel techniques and mechanistic discoveries that advance the study of ssRNA…

ATLAS – Klebsiella phage receptor-binding protein

A new study from Mostowy's lab in Poland on "Structural modularity of receptor-binding proteins underlies host-range strategy diversification in Klebsiella pneumoniae phages" shows the importance of using structural modelling in determining phage-bacterial…

How can polyvalent phage shape bacterial dynamics?

A new paper published in J. Virology, "A polyvalent phage shapes bacterial dynamics" Phages are the most abundant biological entity on the planet, but polyvalent phages that infect multiple bacterial…

Phage-derived proteins can detach the bacterial pilus

Recently published in JBac, "Phage-derived proteins and conjugates induce pilus detachment" Acinetobacter species are environmental bacteria and members of the ESKAPE pathogens, associated with hospital-acquired infections among immunocompromised patients. Rising…

Phage Engineering

Natural phages Vs. Synthetic phages Image from Huss and Raman, 2020. These are some of the important articles in phage engineering / synthetic phages for applications. https://doi.org/10.1016/j.copbio.2019.11.013 https://doi.org/10.7554/eLife.63775 https://www.cell.com/iscience/fulltext/S2589-0042(25)02560-X https://doi.org/10.1016/j.cell.2019.09.015…

Map of Clinical Phage Therapy

The Global Map of Clinical Phage Therapyhttps://www.thephagetherapy.com/p/phagetrials.html An interactive global atlas of bacteriophage therapy clinical trials powered by live ClinicalTrials.gov data.

NEW Publication!! Characterization of Two Salmonella Myoviruses and a Novel Lysis-Inhibition System

https://journals.sagepub.com/doi/10.1177/26416549261444851 Characterization of Two Salmonella Myoviruses and a Novel Lysis-Inhibition System Abstract Background: Salmonella-infecting phages are an attractive alternative for treating antibiotic-resistant infections. Here, we aimed to isolate Salmonella phages and study their lysis…

Not negative, but needs attention – Phage Therapy Future

30 Apr 202630 Apr 2026

Cross-reactive anti-prophage antibodies and bacterial heteroresistance implicated in phage therapeutic failure https://www.nature.com/articles/s41591-026-04301-0 Abstract: Phage therapy is an exciting strategy against antimicrobial-resistant bacterial infections, but critical knowledge gaps regarding its clinical…

New discovery challenges the genetic code’s central dogma

19 Apr 202613 May 2026

Scientists stunned by ‘fundamentally new way’ life produces DNA Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase https://www.science.org/doi/10.1126/science.aed1656 Abstract: Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage…

Boost antibody response using phage therapy

Phage-steering permits antibody-mediated clearance of E. coli K1 from the gut Abstract: Escherichia coli (E. coli) strains expressing the capsule serotype K1 (E. coli K1) are a prevalent cause of neonatal sepsis and meningitis.…