Blog

Cross-reactive anti-prophage antibodies and bacterial heteroresistance implicated in phage therapeutic failure https://www.nature.com/articles/s41591-026-04301-0 Abstract: Phage therapy is an exciting strategy against antimicrobial-resistant bacterial infections, but critical knowledge gaps regarding its clinical…

Scientists stunned by ‘fundamentally new way’ life produces DNA Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase https://www.science.org/doi/10.1126/science.aed1656 Abstract: Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage…

Phage-steering permits antibody-mediated clearance of E. coli K1 from the gut Abstract: Escherichia coli (E. coli) strains expressing the capsule serotype K1 (E. coli K1) are a prevalent cause of neonatal sepsis and meningitis.…

Ecological partitioning enables phage–antibiotic cooperation in a human Pseudomonas infection Abstract: Bacteriophage–antibiotic coadministration is increasingly used for refractory infections, yet the in vivo interactions among phages, bacteria, antibiotics, and host immunity remain…

A new study published in Nature shows that three lysis proteins in small RNA phages inhibit bacterial growth by blocking the MurJ (lipid II flippase) in PG synthesis. Highlights: Antimicrobial…

Combined bacteriophage and antibiotic therapy for refractory peritoneal dialysis-related peritonitis caused by Klebsiella pneumoniae Abstract: Phage therapy is emerging as a promising alternative to antibiotics for treating various infections. However,…

A prophage-expressed type IV pilus component provides anti-phage defense https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01531-1 Summary: Phage genomes integrated into bacterial genomes, known as prophages, frequently encode proteins that provide defence against subsequent phage infection.…

Phage Therapy Market – Overview (2026–2035) Market Size & Forecast The global phage therapy market is projected to grow from USD 0.06 billion in 2026 to USD 0.22 billion by…

The Lysis cassette of jumbophage PhiKZ Manohar, P*., Wan, J., Ganser, G. et al. The Lysis cassette of jumbophage PhiKZ. Sci Rep (2026). https://doi.org/10.1038/s41598-026-36188-9 Abstract: Pseudomonas jumbophage phiKZ is prominent because of the proteinaceous nuclear…