Dr. Prasanth Manohar, Ph.D.

Bad Bugs; New Drugs




Cell (E. coli) lysis. [Induced lambdoid lysis genes of phage S21]

The mechanism of bacterial killing by small peptides. My study is on the small lysis proteins (“Single Gene Lysis”) carried by RNA phages that can kill the bacteria through different mechanisms. The lysis protein-induced cells show different physiological changes such as bleb formation, filamentation or cytoplasmic vacuolization.