Dr. Prasanth Manohar, Ph.D., – Page 2 – PHAGElogist

NEW Publication!! Characterization of Two Salmonella Myoviruses and a Novel Lysis-Inhibition System

https://journals.sagepub.com/doi/10.1177/26416549261444851 Characterization of Two Salmonella Myoviruses and a Novel Lysis-Inhibition System Abstract Background: Salmonella-infecting phages are an attractive alternative for treating antibiotic-resistant infections. Here, we aimed to isolate Salmonella phages and study their lysis…

Not negative, but needs attention – Phage Therapy Future

30 Apr 202630 Apr 2026

Cross-reactive anti-prophage antibodies and bacterial heteroresistance implicated in phage therapeutic failure https://www.nature.com/articles/s41591-026-04301-0 Abstract: Phage therapy is an exciting strategy against antimicrobial-resistant bacterial infections, but critical knowledge gaps regarding its clinical…

New discovery challenges the genetic code’s central dogma

19 Apr 202613 May 2026

Scientists stunned by ‘fundamentally new way’ life produces DNA Protein-templated synthesis of dinucleotide repeat DNA by an antiphage reverse transcriptase https://www.science.org/doi/10.1126/science.aed1656 Abstract: Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage…

Boost antibody response using phage therapy

Phage-steering permits antibody-mediated clearance of E. coli K1 from the gut Abstract: Escherichia coli (E. coli) strains expressing the capsule serotype K1 (E. coli K1) are a prevalent cause of neonatal sepsis and meningitis.…

Phage–antibiotic cooperation in a human Pseudomonas infection

Ecological partitioning enables phage–antibiotic cooperation in a human Pseudomonas infection Abstract: Bacteriophage–antibiotic coadministration is increasingly used for refractory infections, yet the in vivo interactions among phages, bacteria, antibiotics, and host immunity remain…

MurJ flippase inhibition by phage lysis proteins

A new study published in Nature shows that three lysis proteins in small RNA phages inhibit bacterial growth by blocking the MurJ (lipid II flippase) in PG synthesis. Highlights: Antimicrobial…

Cure: Combined bacteriophage and antibiotic therapy to treat Klebsiella pneumoniae

Combined bacteriophage and antibiotic therapy for refractory peritoneal dialysis-related peritonitis caused by Klebsiella pneumoniae Abstract: Phage therapy is emerging as a promising alternative to antibiotics for treating various infections. However,…

Anti-phage defense using type IV pilus

A prophage-expressed type IV pilus component provides anti-phage defense https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01531-1 Summary: Phage genomes integrated into bacterial genomes, known as prophages, frequently encode proteins that provide defence against subsequent phage infection.…

Phage Therapy Market to Surge Over the Next Decade (2026–2035)

Phage Therapy Market – Overview (2026–2035) Market Size & Forecast The global phage therapy market is projected to grow from USD 0.06 billion in 2026 to USD 0.22 billion by…

Out now in Scientific Reports!!

The Lysis cassette of jumbophage PhiKZ Manohar, P*., Wan, J., Ganser, G. et al. The Lysis cassette of jumbophage PhiKZ. Sci Rep (2026). https://doi.org/10.1038/s41598-026-36188-9 Abstract: Pseudomonas jumbophage phiKZ is prominent because of the proteinaceous nuclear…