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Publication title: "Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA" DOI: 10.1126/science.adq39 Important takeaways: Reverse transcriptase function: Reverse transcriptase has been adapted for cellular defense in prokaryotes.…

Publication title: "Cyanobacteria-cyanophage interactions between freshwater and marine ecosystems based on large-scale cyanophage genomic analysis" https://www.sciencedirect.com/science/article/pii/S0048969724053518 Key points from the study: Cyanophage diversity: A large collection of novel cyanophages was isolated…

Title: "Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial"…

Publication coming soon... Holins As a part of the lytic system of dsDNA phages, holins play two fundamental roles: they create holes in the inner membrane for the release of the endolysins, and determine the…

A new study "Antibacterial effect of phage cocktails and phage-antibiotic synergy against pathogenic Klebsiella pneumoniae" https://journals.asm.org/doi/full/10.1128/msystems.00607-24 ABSTRACT The global rise of antibiotic resistance has renewed interest in phage therapy, as an…

Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial DOI:https://doi.org/10.1016/S1473-3099(24)00424-9…

Bacteriophages as potential antibiotic potentiators in cystic fibrosis: A new model to study the combination of antibiotics with a bacteriophage cocktail targeting dual species biofilms of Staphylococcus aureusand Pseudomonas aeruginosa International Journal…

The pharmaceutical industry continues to be a hotbed of patent innovation. Activity is driven by the evolution of treatment paradigms, and the gravity of unmet needs, as well as the…

Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly Several immune pathways in humans conjugate ubiquitin-like proteins to virus and host molecules as a means of antiviral defence. Here we…

SPECIES: Staphylococcus aureus TREATMENT: Topical bacteriophage It is a muggy February morning, 2040, and Myra is ascending the new rock wall at the climbing gym. Her hands strain to hold on…