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Publication coming soon... Holins As a part of the lytic system of dsDNA phages, holins play two fundamental roles: they create holes in the inner membrane for the release of the endolysins, and determine the…

A new study "Antibacterial effect of phage cocktails and phage-antibiotic synergy against pathogenic Klebsiella pneumoniae" https://journals.asm.org/doi/full/10.1128/msystems.00607-24 ABSTRACT The global rise of antibiotic resistance has renewed interest in phage therapy, as an…

Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial DOI:https://doi.org/10.1016/S1473-3099(24)00424-9…

Bacteriophages as potential antibiotic potentiators in cystic fibrosis: A new model to study the combination of antibiotics with a bacteriophage cocktail targeting dual species biofilms of Staphylococcus aureusand Pseudomonas aeruginosa International Journal…

The pharmaceutical industry continues to be a hotbed of patent innovation. Activity is driven by the evolution of treatment paradigms, and the gravity of unmet needs, as well as the…

Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly Several immune pathways in humans conjugate ubiquitin-like proteins to virus and host molecules as a means of antiviral defence. Here we…

SPECIES: Staphylococcus aureus TREATMENT: Topical bacteriophage It is a muggy February morning, 2040, and Myra is ascending the new rock wall at the climbing gym. Her hands strain to hold on…

Read here: https://doi.org/10.1089/phage.2023.0034 Abstract: Multidrug-resistant infections are a challenge in the healthcare setting and a cause of patient morbidity and mortality. Bacteriophages (phages) are viruses that target and kill bacteria…

Bacteriophages, or phages, are viruses that infect bacteria. They have been known to science for over 100 years and were used as antibacterial agents before penicillin was discovered. The development…

A new study "The zebrafish embryo model: unveiling its potential for investigating phage therapy against methicillin-resistant Staphylococcus aureus infection" Read here: https://doi.org/10.1128/aac.00561-24 Staphylococcus aureus is a challenging pathogenic bacterium due to its antibiotic…