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MICROBIOMES Phage therapy suppresses gut inflammation in IBD The gut microbiota is known to contribute to the pathology of inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis. But…

A patient in a hospital develops an antibiotic-resistant bacterial infection that is untreatable or only treatable with the most toxic of antibiotics. During the 48 hours it takes to identify…

Over 2.8 million Americans get antibiotic-resistant bacterial infections anually, and about 35,000 of those patients do not make it through their infection, according to the Centers for Disease Control and…

Read this great article by Cook et al. at https://www.science.org/doi/10.1126/scitranslmed.abo7793 Abstract Antibiotics have transformed modern medicine. They are essential for treating infectious diseases and enable vital therapies and procedures. However,…

After Ryland ‘Ry’ Young retires on Aug. 31, his students can keep an ear out for his signature jangling of keys in the hallways — the renowned faculty member will…

They are ruthlessly efficient killers, with six spider-like ‘legs’ they use to latch on to their prey, and bulbous heads with 20 faces. When they attack in swarms, they are…

Soon after bacteria-killing viruses were independently discovered by English physician Frederick Twort in 1915 and by French microbiologist Felix d’Herelle in 1917, the tiny microbes were seen to have therapeutic…

Phage-antibiotic combinations to control Pseudomonas aeruginosa-Candida two-species biofilms Authored by Prasanth Manohar, Belinda Loh, Ramesh Nachimuthu, Sebastian Leptihn Abstract Phage-antibiotic combinations to treat bacterial infections are gaining increased attention due to the synergistic effects often observed…

A Lysozyme Murein Hydrolase with Broad-Spectrum Antibacterial Activity from Enterobacter Phage myPSH1140 Nachimuthu Ramesh, Prasanth Manohar, Kandasamy Eniyan, Loganathan Archana, Sudarsanan Athira, Belinda Loh, Long Ma, Sebastian Leptihn https://journals.asm.org/doi/epub/10.1128/aac.00506-22 ABSTRACT Bacteriophages and bacteriophage-derived peptidoglycan hydrolases (endolysins) present promising alternatives for the treatment of infections caused by multidrug…

Targeted suppression of human IBD-associated gut microbiota commensals by phage consortiafor treatment of intestinal inflammation Very interesting work!!! https://doi.org/10.1016/j.cell.2022.07.003 SUMMARY Human gut commensals are increasingly suggested to impact non-communicable diseases,…