Dr. Prasanth Manohar, Ph.D., – Page 3 – PHAGElogist

DnaJ mediates phage sensing

DnaJ mediates phage sensing by the bacterial NLR-related protein bNACHT25 Abstract Bacteria encode a wide range of antiphage systems and a subset of these proteins are homologous to components of…

Armata Pharmaceuticals announces positive phage therapy trials

1 Jun 20251 Jun 2025

Armata Pharmaceuticals Announces Positive Topline Data from the Phase 1b/2a diSArm Study of Intravenously Administered AP-SA02 in Complicated Staphylococcus aureus Bacteremia Armata Pharmaceuticals, Inc. (NYSE American: ARMP) ("Armata" or the…

Special issue: Phage–Antibiotic Combination Therapy

New submissions are welcome! Submit your research to the special issue on "Phage-antibiotic Combination Therapy" in Viruses. I will be serving as a guest editor. https://www.mdpi.com/journal/viruses/special_issues/62FG2XW90A Dear Colleagues, Antibiotic resistance…

Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia

A new article, "Adjunctive phage therapy improves antibiotic treatment of ventilator-associated pneumonia with Pseudomonas aeruginosa" Abstract Bacterial multidrug resistance poses an urgent challenge for the treatment of critically ill patients developing…

WHO: Bacteriophages and their use in combating antimicrobial resistance

Bacteriophages (phages) are viruses that selectively target and kill bacteria. They are the most abundant, commonly occurring natural entities, playing crucial roles in regulating bacterial populations and influencing microbial ecosystems.…

Telomere bacteriophages

A new study reporting N15-like Klebsiella phage "Telomere bacteriophages are widespread and equip their bacterial hosts with potent interbacterial weapons" Abstract: Bacteriophages (phages) are viruses that can kill bacteria, thereby…

Personalized inhaled phage therapy

A new article from Yale University, Center for Phage Biology and Therapy. Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis Bacteriophage (phage) therapy, which uses lytic viruses…

The future of phage therapy in the USA

Following a high-profile success in 2016, the field of phage therapy has been reinvigorated. Numerous biotechnology companies, academic groups, and hospitals are now developing and using phage to treat bacterial…

NEW: C-terminal anchor endolysins

Endolysins—enzymes produced by tailed bacteriophages to degrade bacterial cell walls—have traditionally been classified as canonical or signal-anchor-release (SAR) endolysins. However, expanding viral (meta)genomic data analysis has revealed a third class,…

Imaging techniques show phages in unprecedented detail

Researchers at Pitt have produced the most detailed image to date of a bacteriophage–phage for short–that has allowed them to see for the first time the structural makeup of the…