Dr. Prasanth Manohar, Ph.D., – Page 17 – PHAGElogist

The ‘Rapunzel’ virus: an evolutionary oddity

Extremely long tail provides window into how bacteria-infecting viruses assemble A recent study in the Journal of Biological Chemistry has revealed the secret behind an evolutionary marvel: a bacteriophage with an…

Phage cocktail, AP-PA02, safely lowers P. aeruginosa load

Potential efficacy also reported supports company plans for Phase 2b study AP-PA02, an experimental phage therapy for people with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa respiratory infections, was well tolerated and reduced the bacterial load in…

Escape from phage infection by Gram-positive bacteria

A new article in Nature microbiology by Wohlfahrt et al. describes "L-form conversion in Gram-positive bacteria enables escape from phage infection" Abstract: At the end of a lytic bacteriophage replication…

BiomX reports “impressive” data in first bacteriophage trial

Hope that bacteriophages could represent a new therapeutic strategy for resistant bacterial infections has been bolstered by a study conducted by BiomX in cystic fibrosis (CF) patients. While still early,…

Phage Therapy in Germany-Latest

Phage Therapy in Germany—Update 2023 by Willy et al. Viruses 2023, 15(2), 588; https://doi.org/10.3390/v15020588 Abstract Bacteriophage therapy holds promise in addressing the antibiotic-resistance crisis, globally and in Germany. Here, we provide an overview…

Bacteriophage endolysin powders for therapy

A new article punished in the International Journal of Pharmaceutics describes the "Bacteriophage endolysin powders for inhaled delivery against pulmonary infections" by Wang et al. https://doi.org/10.1016/j.ijpharm.2023.122679 Abstract Endolysins are bacteriophage-encoded…

Targeting Phage Therapy 2023

The 6th World Congress on Targeting Phage Therapy 2023 will take place on June 1-2 at IRIS, Paris, France. Targeting Phage 2023: Questions, Controversies, and What is Next? Targeting Phage…

Regulatory pathway needs to be developed to make the most of phages

A regulatory pathway needs to be developed if the UK is to reap the benefits of bacteriophage therapy, Applied Microbiology International (AMI) has warned. France, Belgium and Poland are already…

Publish in this special issue to communicate your phage research

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Microbiology". Deadline for manuscript submissions: 12 May 2023 Special Issue "Bacteriophages: Infection, Genetics and Therapy" https://www.mdpi.com/journal/life/special_issues/196IPXRO2G Dear Colleagues, Bacteriophages…

The dynamic interplay of bacteriophage, bacteria and the mammalian host

Title: "The dynamic interplay of bacteriophage, bacteria and the mammalian host during phage therapy" AbstractFor decades, biomedically-centered studies of bacteria have focused on mechanistic drivers of disease in their mammalian…