Dr. Prasanth Manohar, Ph.D., – PHAGElogist

Boost antibody response using phage therapy

Phage-steering permits antibody-mediated clearance of E. coli K1 from the gut Abstract: Escherichia coli (E. coli) strains expressing the capsule serotype K1 (E. coli K1) are a prevalent cause of neonatal sepsis and meningitis.…

Phage–antibiotic cooperation in a human Pseudomonas infection

Ecological partitioning enables phage–antibiotic cooperation in a human Pseudomonas infection Abstract: Bacteriophage–antibiotic coadministration is increasingly used for refractory infections, yet the in vivo interactions among phages, bacteria, antibiotics, and host immunity remain…

MurJ flippase inhibition by phage lysis proteins

A new study published in Nature shows that three lysis proteins in small RNA phages inhibit bacterial growth by blocking the MurJ (lipid II flippase) in PG synthesis. Highlights: Antimicrobial…

Cure: Combined bacteriophage and antibiotic therapy to treat Klebsiella pneumoniae

Combined bacteriophage and antibiotic therapy for refractory peritoneal dialysis-related peritonitis caused by Klebsiella pneumoniae Abstract: Phage therapy is emerging as a promising alternative to antibiotics for treating various infections. However,…

Anti-phage defense using type IV pilus

A prophage-expressed type IV pilus component provides anti-phage defense https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01531-1 Summary: Phage genomes integrated into bacterial genomes, known as prophages, frequently encode proteins that provide defence against subsequent phage infection.…

Phage Therapy Market to Surge Over the Next Decade (2026–2035)

Phage Therapy Market – Overview (2026–2035) Market Size & Forecast The global phage therapy market is projected to grow from USD 0.06 billion in 2026 to USD 0.22 billion by…

Out now in Scientific Reports!!

The Lysis cassette of jumbophage PhiKZ Manohar, P*., Wan, J., Ganser, G. et al. The Lysis cassette of jumbophage PhiKZ. Sci Rep (2026). https://doi.org/10.1038/s41598-026-36188-9 Abstract: Pseudomonas jumbophage phiKZ is prominent because of the proteinaceous nuclear…

Happy New Year 2026

Phage N4: host cell lysis

Phage N4 uses a SAR endolysin-holin system for host cell lysis Bacteriophages (phages) are viruses that only kill bacteria. To do so, they use lysis proteins targeted at the structural…

KlebPhaCol: identify a novel Klebsiella phage family

KlebPhaCol: a community-driven resource for Klebsiella research, identified a novel phage family Abstract The growing threat of multidrug-resistant Klebsiella pneumoniae, coupled with its role in gut colonisation, has intensified the search…