A new model to study the combination of antibiotics with a bacteriophage cocktail

Bacteriophages as potential antibiotic potentiators in cystic fibrosis: A new model to study the combination of antibiotics with a bacteriophage cocktail targeting dual species biofilms of Staphylococcus aureusand Pseudomonas aeruginosa

International Journal of Antimicrobial Agents

https://www.sciencedirect.com/science/article/abs/pii/S0924857924001948

  • Dual-species (S. aureus-P. aeruginosa) biofilms in cystic fibrosis are difficult to eradicate.
  • A dual-species model in artificial sputum medium was set up.
  • Combinations of broad-spectrum antibiotics and phages were tested.
  • Synergy was observed between antibiotics and phages to reduce biofilm biomass.
  • Synergy on CFU in biofilm was observed only for phages active at low MOI.
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Published by Dr. Prasanth Manohar, Ph.D.,

Early career researcher in the field of Microbiology. Phage biologist, Author, Editor and Scientific writer. Expertise is in bacteriophage biology & genetics, Phage Therapy, ssRNA phages, Phage lysis systems, Single-cell analysis, protein antibiotics, and Antibiotic Resistance.