Phage-antibiotic combinations in various treatment modalities to manage MRSA infections
The study explored the combined impact of the staph phage vB_Sau_S90 and four antibiotics on methicillin-resistant Staphylococcus aureus (MRSA). Three different treatment sequences were examined, showing increased plaque size with the addition of antibiotics. Checkerboard analysis indicated a synergistic effect between the phages and antibiotics. In vivo experiments with the Galleria mellonella model demonstrated that the combination of phage-oxacillin effectively eliminated biofilm-infected larvae, resulting in a 80% survival rate. The findings emphasize the advantages of using a combination of phage and antibiotic over using phages alone in the treatment of MRSA infections.
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