Nachimuthu Ramesh, Madhav Madurantakam Royam, Prasanth Manohar, Sebastian Leptihn
Application of Bacteriophages and its Endolysin in Aquaculture as a Biocontrol Measure
Biological Control, 2021, 104678, ISSN 1049-9644,
https://doi.org/10.1016/j.biocontrol.2021.104678.
(https://www.sciencedirect.com/science/article/pii/S1049964421001481)
Abstract: Aquaculture being a prime source of food for the majority of the global population, the industry is facing enormous loss due to infectious diseases. The use of antibiotics in combating infections is a breakthrough for aquaculture in the past, but the rising antibiotic resistance is posing an immense threat to their livelihood due to strict regulatory guidelines. Alternative therapeutic measures are required to continue the aquaculture production to meet the global need. There is anticipation in using bacteriophages, especially as a biocontrol agent. In this review, we have focused on collecting pieces of evidence to support the application of bacteriophages or phage-derived endolysins in aquaculture to fight bacterial infections in a post-antibiotic era. We have also summarised the prospects of phage applications in aquaculture and highlighted the importance of government initiatives in regulating and escorting the reliable method as a biocontrol strategy in a comprehensive manner in the aquaculture industry. In the future, studies have to be accomplished in aquaculture to prove the effectiveness of phages or phage-derived endolysins to intensify their use on a large scale as a prime source of biocontrol agents.
Keywords: Bacteriophages; endolysin; aquaculture; bacterial infections; biocontrol; application of phages
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