Blog – Page 3 – PHAGElogist

Human serum affect sensitivity to phage infection

An interesting observation from Campobasso et al. "Human serum lipids affect Staphylococcus aureus sensitivity to phage infection" Adult human serum in vitro prevents phage lytic activity against S. aureus Foetal calf serum does not affect…

Phage therapy suitability to a patient: A lesson to learn

6 Jul 20256 Jul 2025

How to: assess patient suitability for unlicensed phage therapy in the United Kingdom Phage therapy may be used as an unlicensed medicine in the United Kingdom Naturally occurring phages are…

Could bacteria-eating viruses save your life?

Interesting article in BBC about phage therapy. I found a bacteria-eating virus in my loo - could it save your life? Phage - the friendly virus Phage science may sound…

Intra-phage immunity

Intra-phage immunity: Set a (pro)phage to catch a phage E. coli prophages encode an arsenal of defense systems to protect against temperate phages The classic view of phage biology has long…

Phage-induced protection against bacterial reinfection

6 Jun 20256 Jun 2025

A new article by Xing et al. in PNAS on "Phage-induced protection against lethal bacterial reinfection" Significance In 2021, antimicrobial-resistant bacteria were responsible for 1.14 million deaths and associated with…

DnaJ mediates phage sensing

DnaJ mediates phage sensing by the bacterial NLR-related protein bNACHT25 Abstract Bacteria encode a wide range of antiphage systems and a subset of these proteins are homologous to components of…

Armata Pharmaceuticals announces positive phage therapy trials

1 Jun 20251 Jun 2025

Armata Pharmaceuticals Announces Positive Topline Data from the Phase 1b/2a diSArm Study of Intravenously Administered AP-SA02 in Complicated Staphylococcus aureus Bacteremia Armata Pharmaceuticals, Inc. (NYSE American: ARMP) ("Armata" or the…

Special issue: Phage–Antibiotic Combination Therapy

New submissions are welcome! Submit your research to the special issue on "Phage-antibiotic Combination Therapy" in Viruses. I will be serving as a guest editor. https://www.mdpi.com/journal/viruses/special_issues/62FG2XW90A Dear Colleagues, Antibiotic resistance…

Adjunctive phage therapy improves antibiotic treatment of ventilator-associated-pneumonia

A new article, "Adjunctive phage therapy improves antibiotic treatment of ventilator-associated pneumonia with Pseudomonas aeruginosa" Abstract Bacterial multidrug resistance poses an urgent challenge for the treatment of critically ill patients developing…

WHO: Bacteriophages and their use in combating antimicrobial resistance

Bacteriophages (phages) are viruses that selectively target and kill bacteria. They are the most abundant, commonly occurring natural entities, playing crucial roles in regulating bacterial populations and influencing microbial ecosystems.…