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Phage-antibiotic combinations to control Pseudomonas aeruginosa-Candida two-species biofilms Authored by Prasanth Manohar, Belinda Loh, Ramesh Nachimuthu, Sebastian Leptihn Abstract Phage-antibiotic combinations to treat bacterial infections are gaining increased attention due to the synergistic effects often observed…

A Lysozyme Murein Hydrolase with Broad-Spectrum Antibacterial Activity from Enterobacter Phage myPSH1140 Nachimuthu Ramesh, Prasanth Manohar, Kandasamy Eniyan, Loganathan Archana, Sudarsanan Athira, Belinda Loh, Long Ma, Sebastian Leptihn https://journals.asm.org/doi/epub/10.1128/aac.00506-22 ABSTRACT Bacteriophages and bacteriophage-derived peptidoglycan hydrolases (endolysins) present promising alternatives for the treatment of infections caused by multidrug…

Targeted suppression of human IBD-associated gut microbiota commensals by phage consortiafor treatment of intestinal inflammation Very interesting work!!! https://doi.org/10.1016/j.cell.2022.07.003 SUMMARY Human gut commensals are increasingly suggested to impact non-communicable diseases,…

Finding that the COVID-19 pandemic disrupted best antibiotic practices and efforts to reduce antimicrobial-resistant infections, the Centers for Disease Control and Prevention (CDC) announced plans to strengthen antibiotic stewardship and…

Bacteriophage research: Antibacterial efficacy of lytic phages against multidrug-resistant Pseudomonas aeruginosainfections in bacteraemia mice models Shri Natrajan Arumugam, Prasanth Manohar, Sunilkumar Sukumaran, Sathish Sadagopan, Belinda Loh, Sebastian Leptihn & Ramesh Nachimuthu  BMC Microbiology volume 22, Article number: 187 (2022)  Abstract Background Pseudomonas aeruginosa is…

Texas A&M University Center for Phage Technology study contributors, left to right: James Clark, research specialist; Tram Le, technical laboratory coordinator; Mei Liu, Ph.D., program director; and Jason Gill, Ph.D., professor…

Two new research articles published in Nature Microbiology; Phage defence by deaminase-mediated depletion of deoxynucleotides in bacteriaBacteria deplete deoxynucleotides to defend against bacteriophage infection

Therapeutic effectiveness of bacteriophage in the treatment of pneumonia caused by NDM-4 producing in a mouse model Author Details : VinodKumar C.S*, Srinivasa H, Chirag Arun Kumar, Suneeta Kalasuramath, B.S Prasad, Jayasimha V.L, Ramesh Nachimuthu, Prasanth Manohar Volume : 7, Issue : 2, Year : 2022 Article Page : 78-84 https://doi.org/10.18231/j.ijirm.2022.019 Abstract…

Bacteria with resistance to multiple antibiotics are a growing problem worldwide. As a result, some types of infections are becoming increasingly difficult to treat, especially in healthcare facilities and in…

In February 2016, infectious disease epidemiologist Steffanie Strathdee was holding her dying husband's hand, watching him lose an exhausting fight against a deadly superbug infection. After months of ups and…