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Author: Dr. Prasanth Manohar, Ph.D.,

Early career researcher in the field of Microbiology. Phage biologist, Author, Editor and Scientific writer. Expertise is in bacteriophage biology & genetics, Phage Therapy, ssRNA phages, Phage lysis systems, Single-cell analysis, protein antibiotics, and Antibiotic Resistance.
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Gene synthesis from a non-coding RNA 

1 Sep 20241 Sep 2024
Publication title: "Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA" DOI: 10.1126/science.adq39 Important takeaways: Reverse transcriptase function: Reverse transcriptase has been adapted for cellular defense in prokaryotes.…
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Large-scale cyanophage genomic analysis

1 Sep 20241 Sep 2024
Publication title: "Cyanobacteria-cyanophage interactions between freshwater and marine ecosystems based on large-scale cyanophage genomic analysis" https://www.sciencedirect.com/science/article/pii/S0048969724053518 Key points from the study: Cyanophage diversity: A large collection of novel cyanophages was isolated…
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A CRISPR-Cas3-enhanced bacteriophage cocktail to treat urinary tract infections 

1 Sep 2024
Title: "Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial"…
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Discovered a new type of holin(s)-Lysis lab

30 Aug 202430 Aug 2024
Publication coming soon... Holins As a part of the lytic system of dsDNA phages, holins play two fundamental roles: they create holes in the inner membrane for the release of the endolysins, and determine the…
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Antibacterial effect of phage cocktails and phage-antibiotic synergy

24 Aug 202424 Aug 2024
A new study "Antibacterial effect of phage cocktails and phage-antibiotic synergy against pathogenic Klebsiella pneumoniae" https://journals.asm.org/doi/full/10.1128/msystems.00607-24 ABSTRACT The global rise of antibiotic resistance has renewed interest in phage therapy, as an…
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Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail

14 Aug 202414 Aug 2024
Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial DOI:https://doi.org/10.1016/S1473-3099(24)00424-9…
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A new model to study the combination of antibiotics with a bacteriophage cocktail

9 Aug 20249 Aug 2024
Bacteriophages as potential antibiotic potentiators in cystic fibrosis: A new model to study the combination of antibiotics with a bacteriophage cocktail targeting dual species biofilms of Staphylococcus aureusand Pseudomonas aeruginosa International Journal…
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Microbiome: the leading companies in bacteriophage therapy

4 Aug 20244 Aug 2024
The pharmaceutical industry continues to be a hotbed of patent innovation. Activity is driven by the evolution of treatment paradigms, and the gravity of unmet needs, as well as the…
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Ubiquitin-like proteins: To be known

25 Jul 202425 Jul 2024
Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly Several immune pathways in humans conjugate ubiquitin-like proteins to virus and host molecules as a means of antiviral defence. Here we…
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The enemy of my enemy is my friend

19 Jul 202419 Jul 2024
SPECIES: Staphylococcus aureus TREATMENT: Topical bacteriophage It is a muggy February morning, 2040, and Myra is ascending the new rock wall at the climbing gym. Her hands strain to hold on…

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Dr. Prasanth Manohar, PhD
Staff Scientist,
Biochemistry and Biology, HMU Health and Medical University, Erfurt, Germany. Plaußiger Straße 9, 04318 Leipzig

Reach me:
Mobile:
+49 (0)162 5326812
+91-96005 08051

E-mail:
prasanth.phage@gmail.com
prasanth.manohar@hmu-erfurt.de
prasanthmanohar.phd@gmail.com

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