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Author: Dr. Prasanth Manohar, Ph.D.,

Early career researcher in the field of Microbiology. Phage biologist, Author, Editor and Scientific writer. Expertise is in bacteriophage biology & genetics, Phage Therapy, ssRNA phages, Phage lysis systems, Single-cell analysis, protein antibiotics, and Antibiotic Resistance.
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ShigActiveâ„¢, Phase 1 Randomized, Double-Blind Clinical Trial

10 Sep 2024
Title: "Safety and Tolerability of ShigActiveâ„¢, a Shigella spp. Targeting Bacteriophage Preparation, in a Phase 1 Randomized, Double-Blind, Controlled Clinical Trial" https://www.mdpi.com/2079-6382/13/9/858 Bacterial diseases of the GI tract are a major global…
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Phage editing technology

6 Sep 20246 Sep 2024
As antibiotic resistance becomes an increasingly serious threat to our health, the scientific and medical communities are searching for new medicines to fight infections. Researchers at Gladstone Institutes have just…
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Gene synthesis from a non-coding RNA 

1 Sep 20241 Sep 2024
Publication title: "Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA" DOI: 10.1126/science.adq39 Important takeaways: Reverse transcriptase function: Reverse transcriptase has been adapted for cellular defense in prokaryotes.…
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Large-scale cyanophage genomic analysis

1 Sep 20241 Sep 2024
Publication title: "Cyanobacteria-cyanophage interactions between freshwater and marine ecosystems based on large-scale cyanophage genomic analysis" https://www.sciencedirect.com/science/article/pii/S0048969724053518 Key points from the study: Cyanophage diversity: A large collection of novel cyanophages was isolated…
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A CRISPR-Cas3-enhanced bacteriophage cocktail to treat urinary tract infections 

1 Sep 2024
Title: "Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial"…
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Discovered a new type of holin(s)-Lysis lab

30 Aug 202430 Aug 2024
Publication coming soon... Holins As a part of the lytic system of dsDNA phages, holins play two fundamental roles: they create holes in the inner membrane for the release of the endolysins, and determine the…
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Antibacterial effect of phage cocktails and phage-antibiotic synergy

24 Aug 202424 Aug 2024
A new study "Antibacterial effect of phage cocktails and phage-antibiotic synergy against pathogenic Klebsiella pneumoniae" https://journals.asm.org/doi/full/10.1128/msystems.00607-24 ABSTRACT The global rise of antibiotic resistance has renewed interest in phage therapy, as an…
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Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail

14 Aug 202414 Aug 2024
Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial DOI:https://doi.org/10.1016/S1473-3099(24)00424-9…
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A new model to study the combination of antibiotics with a bacteriophage cocktail

9 Aug 20249 Aug 2024
Bacteriophages as potential antibiotic potentiators in cystic fibrosis: A new model to study the combination of antibiotics with a bacteriophage cocktail targeting dual species biofilms of Staphylococcus aureusand Pseudomonas aeruginosa International Journal…
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Microbiome: the leading companies in bacteriophage therapy

4 Aug 20244 Aug 2024
The pharmaceutical industry continues to be a hotbed of patent innovation. Activity is driven by the evolution of treatment paradigms, and the gravity of unmet needs, as well as the…

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Dr. Prasanth Manohar, PhD.
Postdoctoral Research Associate
Center For Phage Technology (CPT)
Department of Biochemistry And Biophysics 
Room No. BICH 437A 
Texas A&M AgriLife Research
Texas A&M University

300 Olsen Blvd, 2128 TAMU
College Station, Texas 77843, USA

Reach me:
Mobile:
 +1 (979) 218-2675
+91 96005 08051

E-mail:
prasanth.emsa1@gmail.com
prasanth.manohar@ag.tamu.edu
prasanthmanohar@tamu.edu

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