Dr. Prasanth Manohar, Ph.D., – Page 37 – PHAGElogist

Locus Biosciences to develop K. pneumoniae-targeting phage therapy

Locus Biosciences will develop its LBP-KP01, CRISPR-Cas3-enhanced bacteriophage product targeting Klebsiella pneumoniae with a $12.5 million partnership with the global nonprofit Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X). LBP-KP01 is a bacteriophage cocktail engineered…

Transfer of Antibiotic Resistance Genes from Gram-positive to Gram-negative Bacterium

New Publication from my research group: Abstract The emergence of antibiotic resistance due to uncontrolled use of antibiotics in non-humans, poses a major threat for treating bacterial infections in humans.…

Drug-resistant superbug thriving in hospitals hit hard by COVID-19

OVER CHRISTMAS BREAK in 2015, Johanna Rhodes received a panicked email from a doctor working at the Royal Brompton Hospital, the largest heart and lung center in the United Kingdom. A…

Clinical Trial of AP-PA02 Phage Therapy for P. aeruginosa Infections

The U.S. Food and Drug Administration (FDA) cleared Armata Pharmaceuticals‘ investigational new drug (IND) application for a Phase 1b/2a clinical trial of AP-PA02 for the treatment of the Pseudomonas aeruginosa bacterial infections that are a hallmark of cystic fibrosis (CF). “We…

A Biological Inventory of Prophages in A. baumannii Genomes

New publication from our lab, "A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length and Genomic Positions" authored by Belinda Loh, Jiayuan Chen, Prasanth Manohar, Yunsong Yu, Xiaoting Hua, Sebastian Leptihn Link: https://www.biorxiv.org/content/10.1101/2020.10.26.355222v1 Abstract Acinetobacter…

Phage Lab Finds Success with Hybrid Approach

During what Kristen Butela, lecturer in the Department of Biological Sciences in the Kenneth P. Dietrich School of Arts and Sciences, half-jokingly refers to as “The Before Times,” her course-based undergraduate research class Foundations…

Phage Sensitivity Test in India

In A First, Dr Dangs Lab Begins Bacteriophage Susceptibility Testing To Combat Antibiotic Resistance In an initiative that will enable thousands of Indians suffering from unresolved and antibiotic-resistant bacterial infections…

Antimicrobial resistance in South-East Asia

Antimicrobial agents have played a critical role in reducing the burden of communicable diseases across the world. The WHO South-East Asia Region is no exception. Region-wide, antimicrobial drugs, including antibiotics,…

How pharma sector can contribute to contain the “Superbugs” menace in India

ndia has one of the world’s highest number of bacterial infections; tuberculosis, cholera, typhoid, pneumonia and a host of them. In fact, the country has the highest number of tuberculosis patients…

Sensei raises $29M to advance anti-cancer bacteriophage pipeline

Sensei Biotherapeutics has raised $28.5 million to advance a pipeline of personalized cancer drugs. The financing round comes weeks after Sensei shared clinical data on the effect of combining its lead asset…