Dr. Prasanth Manohar, Ph.D., – Page 22 – PHAGElogist

Modification of the immune response by bacteriophages

Modification of the immune response by bacteriophages alters methicillin-resistant Staphylococcus aureus infection Scientific Reports volume 12, Article number: 15656 (2022) Abstract: There is an urgent need to develop phage therapies for multidrug-resistant bacterial infections. However, although bacteria…

Development of host immune response to bacteriophage

Development of host immune response to bacteriophage in a lung transplant recipient on adjunctive phage therapy for a multidrug resistant pneumonia 10.1093/infdis/jiac368 Abstract Bacteriophage therapy is the use of viruses…

New publication in Nature Microbiology

Widespread stop-codon recoding in bacteriophages may regulate translation of lytic genes Nature Microbiology volume 7, pages 918–927 (2022) https://www.nature.com/articles/s41564-022-01128-6 Abstract: Bacteriophages (phages) are obligate parasites that use host bacterial translation machinery to produce viral…

Phage therapy in IBD

MICROBIOMES Phage therapy suppresses gut inflammation in IBD The gut microbiota is known to contribute to the pathology of inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis. But…

TAILOR achieves clinical success with phage therapy

A patient in a hospital develops an antibiotic-resistant bacterial infection that is untreatable or only treatable with the most toxic of antibiotics. During the 48 hours it takes to identify…

Using Nanoantibiotics to Counter Antibiotic Resistance Gains US Patent

Over 2.8 million Americans get antibiotic-resistant bacterial infections anually, and about 35,000 of those patients do not make it through their infection, according to the Centers for Disease Control and…

The past, present, and future of antibiotics

Read this great article by Cook et al. at https://www.science.org/doi/10.1126/scitranslmed.abo7793 Abstract Antibiotics have transformed modern medicine. They are essential for treating infectious diseases and enable vital therapies and procedures. However,…

Celebrating Ryland Young’s career, advances in phage applications

After Ryland ‘Ry’ Young retires on Aug. 31, his students can keep an ear out for his signature jangling of keys in the hallways — the renowned faculty member will…

How an army of ‘friendly viruses’ fighting a war on superbugs

They are ruthlessly efficient killers, with six spider-like ‘legs’ they use to latch on to their prey, and bulbous heads with 20 faces. When they attack in swarms, they are…

Phage Therapy Starts Realizing Its Long-Deferred Potential

Soon after bacteria-killing viruses were independently discovered by English physician Frederick Twort in 1915 and by French microbiologist Felix d’Herelle in 1917, the tiny microbes were seen to have therapeutic…