Dr. Prasanth Manohar, Ph.D., – Page 15 – PHAGElogist

Non-alcoholic fatty liver disease: Bacteriophages to treat Klebsiella pneumoniae

Abstract Our previous studies have shown that high alcohol-producing Klebsiella pneumoniae (HiAlc Kpn) in the intestinal microbiome could be one of the causes of non-alcoholic fatty liver disease (NAFLD). Considering antimicrobial resistance of K.…

Advancements in bacteriophage therapies

Advancements in bacteriophage therapies and delivery for bacterial infection DOI: 10.1039/D2MA00980C (Review Article) Mater. Adv., 2023, 4, 1249-1257 Abstract Having co-evolved with bacteria over hundreds of millions of years, bacteriophage are effective killers of…

The Other Side: Analysis of phage therapy

Case report: Analysis of phage therapy failure in a patient with a Pseudomonas aeruginosaprosthetic vascular graft infection https://doi.org/10.3389/fmed.2023.1199657 Clinical case of a patient with a Pseudomonas aeruginosa multidrug-resistant prosthetic vascular graft infection which…

Robust pipeline of antibiotic treatments to combat antimicrobial resistance (AMR) – WHO

AMR was associated with nearly 5 million deaths in 2019, however the R&D pipeline for new antibiotics is thin and access to new and existing treatments remains a challenge. WHO,…

Good Virus: The tiny entities that infect bacteria

Phages—tiny entities that infect bacteria—were discovered over 100 years ago but were largely abandoned as therapies. Now they’re making a comeback. Bacteriophages—or phages for short—are microscopic viruses even smaller than…

Roots of antibiotic resistance

Bacteria naturally adapt to various environmental stimuli and as they mutate, these changes can make them resistant to drugs that would kill or slow their growth. Comparative visualization of domains…

A novel phage lysin to kill Gram-negative ESKAPE pathogens

PlyKp104, a Novel Phage Lysin for the Treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Other Gram-Negative ESKAPE Pathogens Antimicrobial Chemotherapy, https://doi.org/10.1128/aac.01519-22 ABSTRACT Klebsiella pneumoniae and Pseudomonas aeruginosa are two leading causes of burn and wound…

Inhalation phage therapy to prevent secondary bacterial pneumonia

Inhalation phage therapy as a new approach to preventing secondary bacterial pneumonia in patients with moderate to severe COVID-19: A double-blind clinical trial study Journal of Drug Delivery Science and…

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Compassionate use of bacteriophages – Israeli Phage Therapy Center

The compassionate use of bacteriophages for failed persistent infections during the first five years of the Israeli Phage Therapy Center (IPTC) Open Forum Infectious Diseases, ofad221, https://doi.org/10.1093/ofid/ofad221 Abstract The use of…