Dr. Prasanth Manohar, Ph.D., – Page 13 – PHAGElogist

RNA phage genome entry

18 Dec 202318 Dec 2023

An interesting article "An outermembrane determinant for RNA phage genome entry in Pseudomonas aeruginosa" by Bae et al., in iScience. Read here: https://doi.org/10.1016/j.isci.2023.108675 SUMMARY: Host range of a phage is determined…

Bacteriophage therapy: From lab to clinical practice

Interaction of Bacteriophages with the Immune System: Induction of Bacteriophage-Specific Antibodies Abstract In all cases when a bacteriophage makes a direct contact with a mammalian organism, it may challenge the…

CNN’s ‘Vital Signs’ on phage therapy

5 Dec 202311 Dec 2023

Antibiotics have been hailed as a "miracle drug" since the discovery of penicillin in 1928, but now, more bacteria are developing resistance to antibiotics. In 2019, the United Nations estimated…

Designing phage cocktail

3 Dec 202311 Dec 2023

Read here: https://journals.asm.org/doi/full/10.1128/spectrum.01258-23 Phage therapy, an emerging strategy in the fight against recalcitrant bacterial infections, encounters a significant hurdle posed by the development of phage-resistant bacterial strains. To address this…

Pseudomonas aeruginosa Phage

30 Nov 202311 Dec 2023

The use of Pseudomonas aeruginosa Phage PASA16 for non resolving infections Abstract Background A growing number of compassionate phage therapy use cases reported in the last decade, with only a limited number…

Fecal Transplantation of Klebsiella pneumoniae and its Bacteriophages

30 Nov 202311 Dec 2023

A Longitudinal Study of The Effect of Fecal Microbiota Transplantation on Klebsiella pneumoniae and its Bacteriophages in a Patient with Long-Term Colonization Abstract Background Live biotherapeutic products such as fecal microbiota transplantation…

Phage Therapy in Lung Transplantation

9 Nov 202311 Dec 2023

An impactful review article on phage therapy by Saima Aslam, IPATH After the seminal case of intravenous phage therapy in the United States in 2016, the past 7 years have…

Phage preparation for therapy

7 Nov 202311 Dec 2023

Magistral Phage Preparations: Is This the Model for Everyone?BY Jean-Paul Pirnay, Gilbert Verbeken Abstract Phage therapy is increasingly put forward as a promising additional tool to help curb the global antimicrobial…

Phage cocktail BX004 reduces P. aeruginosa in small trial

3 Nov 202311 Dec 2023

BX004, BiomX’s experimental phage cocktail — a treatment that uses certain viruses to kill disease-causing microorganisms — was seen to reduce the number of Pseudomonas aeruginosa bacteria present in the lungs of people with cystic…

Phage therapy shows promise for antibiotic-resistant infections

3 Nov 202311 Dec 2023

Bacteriophage therapy could be a promising approach for treating antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa infections in people with cystic fibrosis (CF), according to a small review study. Scientists believe the review, involving three CF patients…