Dr. Prasanth Manohar, Ph.D., – Page 11 – PHAGElogist

Phage Therapy: Optimized preparation pipeline

2 Feb 20242 Feb 2024

Optimized preparation pipeline for emergency phage therapy against Pseudomonas aeruginosa at Yale University Bacteriophage therapy is one potential strategy to treat antimicrobial resistant or persistent bacterial infections, and the year 2021 marked…

BARDA Funds CRISPR-Based Bacteriophage Therapy

25 Jan 202425 Jan 2024

Antibiotic-resistant infections are a particular concern with large-scale use of antibiotics to treat secondary infections during a pandemic, such as those caused by H1N1 influenza or SARS-CoV-2, and in treating…

Call for more funding and flexible regulatory framework for phage R&D

Phages that kill bacteria are seen as a possible solution to the waning power of antibiotics. But research funding is lacking and existing routes to approval and commercialisation are not…

Positive and negative aspects of bacteriophages

7 Jan 20247 Jan 2024

Abstract Bacteriophages infect and replicate inside a bacterial host as well as serve as natural bio-control agents. Phages were once viewed as nuisances that caused fermentation failures with cheese-making and…

British MPs call for more research into phages

4 Jan 20244 Jan 2024

A new report by British members of parliament (MPs) is calling on the UK government to address issues hampering research and development of bacteriophage therapy. Interest in phages, which are viruses that…

Phage Therapy in Korea

22 Dec 20234 Jan 2024

New publication from Lee et al. on "Phage therapy in Korea" Abstract Background Concerns about the rise in antimicrobial resistance have led to renewed interest in phage therapy worldwide, but…

Phage Therapy in Patients With Cystic Fibrosis

20 Dec 202320 Dec 2023

Eastern Bloc countries and the Soviet Union use bacteriophage (phage) therapy for bacterial infections. In the United States, phage is only available in compassionate use scenarios, so there is a…

RNA phage genome entry

18 Dec 202318 Dec 2023

An interesting article "An outermembrane determinant for RNA phage genome entry in Pseudomonas aeruginosa" by Bae et al., in iScience. Read here: https://doi.org/10.1016/j.isci.2023.108675 SUMMARY: Host range of a phage is determined…

Bacteriophage therapy: From lab to clinical practice

Interaction of Bacteriophages with the Immune System: Induction of Bacteriophage-Specific Antibodies Abstract In all cases when a bacteriophage makes a direct contact with a mammalian organism, it may challenge the…

CNN’s ‘Vital Signs’ on phage therapy

5 Dec 202311 Dec 2023

Antibiotics have been hailed as a "miracle drug" since the discovery of penicillin in 1928, but now, more bacteria are developing resistance to antibiotics. In 2019, the United Nations estimated…