April 2025 – PHAGElogist

The future of phage therapy in the USA

Following a high-profile success in 2016, the field of phage therapy has been reinvigorated. Numerous biotechnology companies, academic groups, and hospitals are now developing and using phage to treat bacterial…

NEW: C-terminal anchor endolysins

Endolysins—enzymes produced by tailed bacteriophages to degrade bacterial cell walls—have traditionally been classified as canonical or signal-anchor-release (SAR) endolysins. However, expanding viral (meta)genomic data analysis has revealed a third class,…

Imaging techniques show phages in unprecedented detail

Researchers at Pitt have produced the most detailed image to date of a bacteriophage–phage for short–that has allowed them to see for the first time the structural makeup of the…

Sphae: To predict phage therapy candidates

A tool to identify suitable phage candidates for phage therapy. "Sphae: an automated toolkit for predicting phage therapy candidates from sequencing data" Abstract: The authors say "We developed Sphae, an…

Investigational Phage Therapy to treat Diabetic Foot Osteomyelitis

Investigational Phage Therapy Shows Positive Topline Results for Diabetic Foot Osteomyelitis Yesterday, an Israeli-based company, BiomX, announced results from its phase 2 trial studying its investigational phage therapy, BX211, which…