February 2025 – PHAGElogist

First Use of Phage Therapy in Canada

First Use of Phage Therapy in Canada for the Treatment of a Life-Threatening, Multidrug-Resistant Staphylococcus epidermidis Periprosthetic Joint Infection: An N-of-1 Trial Abstract We describe the first use of phage therapy in…

Bacteriophage Therapy in Children

"Clinical Application of Bacteriophage Therapy in Children" Bacteriophages are highly specific in targeting single pathogens in the treat- ment of bacterial infections and thus offer a promising alternative to antibiotic…

New on Phage Therapy

Bacteriophage (phages) are viruses that exclusively use bacterial cells for propagation, killing the bacterial host in the process. In phage therapy, phages are used to reduce bacterial numbers, thereby curing…

phage ΦX174: Chloramphenicol and gentamicin reduce the evolution of resistance

Chloramphenicol and gentamicin reduce the evolution of resistance to phage ΦX174 by suppressing a subset of E. coli LPS mutants https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002952 Bacteriophages infect gram-negative bacteria by attaching to molecules present…

A flagella-dependent Burkholderia jumbo phage

Bacterial plant pathogens threaten many major food crops and inflict large agricultural losses worldwide. B. glumae is a bacterial plant pathogen that causes diseases such as rot, wilt, and blight in several…