1 Sep 2024 – PHAGElogist

Gene synthesis from a non-coding RNA

1 Sep 20241 Sep 2024

Publication title: "Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA" DOI: 10.1126/science.adq39 Important takeaways: Reverse transcriptase function: Reverse transcriptase has been adapted for cellular defense in prokaryotes.…

Large-scale cyanophage genomic analysis

1 Sep 20241 Sep 2024

Publication title: "Cyanobacteria-cyanophage interactions between freshwater and marine ecosystems based on large-scale cyanophage genomic analysis" https://www.sciencedirect.com/science/article/pii/S0048969724053518 Key points from the study: Cyanophage diversity: A large collection of novel cyanophages was isolated…

A CRISPR-Cas3-enhanced bacteriophage cocktail to treat urinary tract infections

Title: "Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial"…