March 2023 – PHAGElogist

New Publication! Staph Phage

Phage-Antibiotic Combination: An Effective Method for Eradication of Staphylococcus aureus Archana Loganathan, Prasanth Manohar, Ramesh Nachimuthu https://www.biorxiv.org/content/10.1101/2023.03.27.534482v1 Abstract Increasing antibiotic resistance poses a serious threat, especially in patients admitted to…

Superbugs Flourish, Bacteriophage Therapy to Rescue

This NEW article in JAMA describes the current status of phage therapy clinical trials As Superbugs Flourish, Bacteriophage Therapy Recaptures Researchers’ Interest JAMA. 2023;329(10):781-784. doi:10.1001/jama.2022.17756 "Three weeks after the patient was…

Publication alert! “Phage Therapy”

The applications of animal models in phage therapy: An update Read here: https://doi.org/10.1080/21645515.2023.2175519 ABSTRACT The rapid increase in antibiotic resistance presents a dire situation necessitating the need for alternative therapeutic…

Bacteria killing too many people: Silent pandemic’ warning from WHO

World Health Organization (WHO) is warning of a 'silent pandemic' due to a lack of antibiotic development. The World Health Organization (WHO) is warning of a "silent pandemic" of antimicrobial resistance from…

The ‘Rapunzel’ virus: an evolutionary oddity

Extremely long tail provides window into how bacteria-infecting viruses assemble A recent study in the Journal of Biological Chemistry has revealed the secret behind an evolutionary marvel: a bacteriophage with an…

Phage cocktail, AP-PA02, safely lowers P. aeruginosa load

Potential efficacy also reported supports company plans for Phase 2b study AP-PA02, an experimental phage therapy for people with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa respiratory infections, was well tolerated and reduced the bacterial load in…

Escape from phage infection by Gram-positive bacteria

A new article in Nature microbiology by Wohlfahrt et al. describes "L-form conversion in Gram-positive bacteria enables escape from phage infection" Abstract: At the end of a lytic bacteriophage replication…