August 2022 – PHAGElogist

How an army of ‘friendly viruses’ fighting a war on superbugs

They are ruthlessly efficient killers, with six spider-like ‘legs’ they use to latch on to their prey, and bulbous heads with 20 faces. When they attack in swarms, they are…

Phage Therapy Starts Realizing Its Long-Deferred Potential

Soon after bacteria-killing viruses were independently discovered by English physician Frederick Twort in 1915 and by French microbiologist Felix d’Herelle in 1917, the tiny microbes were seen to have therapeutic…

New Results! Out Now! read…

Phage-antibiotic combinations to control Pseudomonas aeruginosa-Candida two-species biofilms Authored by Prasanth Manohar, Belinda Loh, Ramesh Nachimuthu, Sebastian Leptihn Abstract Phage-antibiotic combinations to treat bacterial infections are gaining increased attention due to the synergistic effects often observed…

Out Now! Publication alert

A Lysozyme Murein Hydrolase with Broad-Spectrum Antibacterial Activity from Enterobacter Phage myPSH1140 Nachimuthu Ramesh, Prasanth Manohar, Kandasamy Eniyan, Loganathan Archana, Sudarsanan Athira, Belinda Loh, Long Ma, Sebastian Leptihn https://journals.asm.org/doi/epub/10.1128/aac.00506-22 ABSTRACT Bacteriophages and bacteriophage-derived peptidoglycan hydrolases (endolysins) present promising alternatives for the treatment of infections caused by multidrug…

Targeted suppression of human IBD…phage consortia

Targeted suppression of human IBD-associated gut microbiota commensals by phage consortiafor treatment of intestinal inflammation Very interesting work!!! https://doi.org/10.1016/j.cell.2022.07.003 SUMMARY Human gut commensals are increasingly suggested to impact non-communicable diseases,…

Pandemic Prompts CDC to Strengthen Antibiotic Stewardship

Finding that the COVID-19 pandemic disrupted best antibiotic practices and efforts to reduce antimicrobial-resistant infections, the Centers for Disease Control and Prevention (CDC) announced plans to strengthen antibiotic stewardship and…

New Publication!

Bacteriophage research: Antibacterial efficacy of lytic phages against multidrug-resistant Pseudomonas aeruginosainfections in bacteraemia mice models Shri Natrajan Arumugam, Prasanth Manohar, Sunilkumar Sukumaran, Sathish Sadagopan, Belinda Loh, Sebastian Leptihn & Ramesh Nachimuthu BMC Microbiology volume 22, Article number: 187 (2022) Abstract Background Pseudomonas aeruginosa is…